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KMID : 0355620100360040250
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2010 Volume.36 No. 4 p.250 ~ p.254
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The bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) in the calvaria defect of rabbit
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Song Ji-Young
Kweon Hae-Yong
Kwon Kwang-Jun
Park Young-Wook
Kim Seong-Gon
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Abstract
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Introduction: This study evaluated the bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) of a bone defect in rabbits. Materials and
Methods: Ten New Zealand white rabbits were used for this study and bilateral round shaped defects were formed in the parietal bone (diameter: 8.0 mm). The silk fibroin mixed with PRF was grafted into the right parietal bone (experimental group). The left side (control group) was grafted only PRF. The animals were sacrificed at 4 weeks and 8 weeks. A micro-computerized tomography (μCT) of each specimen was taken. Subsequently, the specimens were decalcified and stained for histological analysis.
Results: The average value of plane film analysis was higher in the experimental group than in the control group at 4 weeks and 8weeks after surgery. However, the difference was not statistically significant.(P>0.05) The tissue mineral density (TMD) in the experimental group at 4 weeks after surgery was significantly higher than the control group.(P<0.05)
Conclusion: Silk fibroin can be used as a scaffold of PRF for rabbit calvarial defect repair.
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KEYWORD
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Platelet-rich fibrin (PRF), Silk fibroin, Bone regeneration
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